All a person has to do is cite simple arithmetic to show the lack of success from the animal-model.
The FDA in the USA cites an initial 92% failure rate for those drugs which successfully pass animal trials.
After human clinical trials are completed this increases to a larger 96% failure rate.
Post market drug surveillance over the next few years adds another 3.1% producing just over a GRAND TOTAL of a 99% failure rate!!
If one were to list all research methodologies (there about 40-50 in total), none of these methods failure rates come anywhere near 99%.
Sadly, this 3.1% is the 5th leading cause of death at about 110,000 people due to NONERROR (not side effects) poisonous reactions from these "perfected" animal-tested drugs.
For those who are not killed 15% of all hospital beds are filled with patients from these very same drugs that killed the 110,000!