Philosophy - Index
Testing - Index
Animal Experiments Misled Scientists on
On February 17, John J. Pippin, M.D., FA.C.C., will testify
before Food and Drug Administration (FDA) officials and present a new report
detailing how experiments on mice, dogs, and other animals misled scientists and
ultimately contributed to a tragic outcome for human patients exposed to Vioxx
and other drugs. Dr. Pippin will represent the nonprofit Physicians
Committee for Responsible Medicine (PCRM).
PCRM's report reveals that Vioxx and other COX-2 drugs actually had a
heart-protective effect in mice and other animals, exactly opposite of how the
drugs later performed in humans. The report also reveals that once clinical
trials started showing that the drugs caused heart problems in humans, the
pharmaceutical companies ignored this information and instead pointed to the
animal tests as "evidence" that the drugs were safe. As Dr. Pippin illustrates
in the report, the Vioxx animal testing debacle is not unique. Over the years,
millions of patients have been exposed to harmful drugs, such as Rezulin and
Baycol, that seemed safe in tests on mice, dogs, rats, monkeys, horses, and
"Reliance on animal tests enabled the FDA to approve Vioxx," says Dr. Pippin.
"It is time to turn to newer, more reliable human-based methods such as studying
drug metabolism using human liver subcellular fractions." Liver toxicity is the
major reason for drug re-labeling and withdrawal, and it often does not show up
in dogs and other animals.
For an interview with Dr. Pippin call Jeanne S. McVey, on-site cell phone, (415)